HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NECFESHC~SH3_1, SH3_1~p47_phox_C, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 347
+	Hs
		63093 NCF1B_HUMAN (1-390): 1.01e-100: 305: 98.98		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		537666 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		537645 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		1307430 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		1307429 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		537657 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		537619 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		1307414 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Rn
		192737 SRBS2_RAT (163-283): 2.18e-21: 98.4: 21.15		SH3G1_RAT (1-347): 1.14e-78: 246: 66.30
+	Hs
		1307415 SH3G3_HUMAN (222-285): 2.65e-18: 87.1: 12.50		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		1052195 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Rn
		71363 B2RZ33_RAT (130-350): 1.82e-33: 130: 17.16		SRC8_RAT (7-343): 1.63e-50: 177: 13.53
+	Hs
		1052226 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		RHG17_HUMAN (6-251): 2.42e-35: 138: 20.83
+	Hs
		557655 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		924570 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		1078900 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		209154 NCK2_HUMAN (161-327): 3.03e-19: 90.2: 14.98		SRBS1_HUMAN (169-342): 1.13e-13: 74.1: 17.65
+	Hs
		298986 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		298942 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15
+	Hs
		208967 NCK2_HUMAN (161-327): 3.03e-19: 90.2: 14.98		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15