HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~fn3
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0043235 - receptor complex GO:0043548 - phosphatidylinositol 3-kinase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1297 Hs			1 894
+	Hs
		537718 INSRR_HUMAN (1-1297): 0: 1365: 100.00		EPHA8_HUMAN (2-824): 0: 590: 19.20
+	Hs
		435548 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		411286 INSRR_HUMAN (1-1297): 0: 1365: 100.00		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		411310 INSR_HUMAN (27-1288): 0: 1183: 52.18		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		411275 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		411268 INSR_HUMAN (27-1288): 0: 1183: 52.18		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		435499 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		435522 INSRR_HUMAN (1-1297): 0: 1365: 100.00		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		435619 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		411279 INSR_HUMAN (27-1288): 0: 1183: 52.18		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		411319 INSR_HUMAN (27-1288): 0: 1183: 52.18		RYK_HUMAN (521-810): 4.45e-57: 209: 37.63
+	Hs
		435514 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69
+	Hs
		435496 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		665385 EPHA3_HUMAN (453-1255): 0: 617: 21.02		EPHA4_HUMAN (2-836): 0: 637: 19.40
+	Hs
		665383 EPHA3_HUMAN (453-1255): 0: 617: 21.02		EPHA5_HUMAN (2-812): 0: 622: 20.39
+	Hs
		665399 EPHA3_HUMAN (453-1255): 0: 617: 21.02		EPHA7_HUMAN (2-837): 0: 621: 19.50
+	Hs
		665374 EPHA3_HUMAN (453-1255): 0: 617: 21.02		EPHB2_HUMAN (2-837): 0: 605: 19.58
+	Hs
		665142 EPHA3_HUMAN (453-1255): 0: 617: 21.02		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		665384 EPHA3_HUMAN (453-1255): 0: 617: 21.02		EPHB4_HUMAN (2-836): 1.08e-180: 549: 20.49