HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1297 Hs			1 412
+	Hs
		118686 INSRR_HUMAN (1-1297): 0: 1365: 100.00		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		537736 INSRR_HUMAN (1-1297): 0: 1365: 100.00		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		118695 EPHA8_HUMAN (454-1268): 2.42e-179: 558: 20.16		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		118645 EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		872531 EPHB4_HUMAN (455-1269): 0: 581: 21.32		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		171301 EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		384834 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00
+	Hs
		384721 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		PPID_HUMAN (5-369): 4.48e-66: 216: 18.06
+	Hs
		118696 LTK_HUMAN (969-1291): 4.92e-73: 264: 42.17		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		118739 NTRK2_HUMAN (957-1253): 1.12e-67: 247: 42.43		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		118668 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		384676 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18
+	Hs
		169174 MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		384359 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00
+	Hs
		384787 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		601874 ERBB3_HUMAN (2-296): 3.16e-34: 145: 18.24		FKB1A_HUMAN (101-204): 1.72e-35: 128: 32.41
+	Hs
		923826 ERBB4_HUMAN (342-482): 7.06e-15: 82.4: 19.73		FKB1A_HUMAN (101-204): 1.72e-35: 128: 32.41
+	Rn
		193482 INSR_RAT (5-179): 3.17e-10: 67: 19.78		STIP1_RAT (218-376): 1.61e-19: 92.7: 18.24