HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: DSC3 (Q14574)
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Gene: DSC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1297 Hs			1 896
+	Hs
		435643 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		DSC3_HUMAN (1-896): 0: 847: 100.00
+	Hs
		411386 INSR_HUMAN (27-1288): 0: 1183: 52.18		DSC3_HUMAN (1-896): 0: 847: 100.00
+	Hs
		435534 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		CADH3_HUMAN (10-891): 0: 577: 27.49
+	Hs
		435531 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		872600 EPHB4_HUMAN (455-1269): 0: 581: 21.32		PCDG6_HUMAN (1-818): 0: 732: 18.48
+	Hs
		872602 EPHB4_HUMAN (455-1269): 0: 581: 21.32		PCDA8_HUMAN (2-470): 1.82e-86: 298: 16.16
+	Hs
		872601 EPHB4_HUMAN (455-1269): 0: 581: 21.32		PCDG5_HUMAN (2-464): 1.03e-81: 284: 17.86
+	Hs
		872598 EPHB4_HUMAN (455-1269): 0: 581: 21.32		PCDB3_HUMAN (2-475): 2.75e-78: 272: 15.99
+	Hs
		580213 EPHA4_HUMAN (455-1279): 0: 609: 20.55		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		580236 EPHA7_HUMAN (454-1280): 0: 598: 20.58		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		600717 EPHA1_HUMAN (657-1279): 2.19e-159: 505: 23.51		PCDA8_HUMAN (2-470): 1.82e-86: 298: 16.16
+	Hs
		872632 EPHA4_HUMAN (455-1279): 0: 609: 20.55		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83
+	Hs
		971014 EPHA7_HUMAN (454-1280): 0: 598: 20.58		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83
+	Hs
		665396 EPHA3_HUMAN (453-1255): 0: 617: 21.02		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		521744 EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20		CADH1_HUMAN (2-464): 1.66e-38: 157: 15.98
+	Hs
		872427 EPHA5_HUMAN (454-1279): 0: 591: 19.78		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83
+	Hs
		872645 EPHA4_HUMAN (455-1279): 0: 609: 20.55		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		1048589 EPHA7_HUMAN (454-1280): 0: 598: 20.58		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		872440 EPHA5_HUMAN (454-1279): 0: 591: 19.78		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		665215 EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83