HitPredict - High confidence protein-protein interactions

Interactor 1: KPYM (P14618)
Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)
Gene: PKM

Interactor 2: KPYM (P14618)
Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)
Gene: PKM

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	24344305, 23064226
Identification Methods	affinity chromatography technology, x-ray crystallography
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK~PK, PK~PK_C, PK_C~PK_C
Common GO terms	GO:0000287 - magnesium ion binding GO:0003713 - transcription coactivator activity GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0004713 - protein tyrosine kinase activity and 28 others more... GO:0004743 - pyruvate kinase activity GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005791 - rough endoplasmic reticulum GO:0005829 - cytosol GO:0005929 - cilium GO:0006096 - glycolytic process GO:0012501 - programmed cell death GO:0016310 - phosphorylation GO:0023026 - MHC class II protein complex binding GO:0030955 - potassium ion binding GO:0031982 - vesicle GO:0032869 - cellular response to insulin stimulus GO:0034774 - secretory granule lumen GO:0035402 - histone H3T11 kinase activity GO:0042803 - protein homodimerization activity GO:0045296 - cadherin binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061621 - canonical glycolysis GO:0062023 - collagen-containing extracellular matrix GO:0070062 - extracellular exosome GO:1903561 - extracellular vesicle GO:1903672 - positive regulation of sprouting angiogenesis GO:1904813 - ficolin-1-rich granule lumen GO:2000767 - positive regulation of cytoplasmic translation
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1	531
Hs

1	531

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Last updated: 15 Jul 2024