HitPredict

Interactor 1: KPYM (P14618)
Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)
Gene: PKM

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 531 Hs			1 768
+	Hs
		537900 KPYM_HUMAN (1-531): 0: 801: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		675046 KPYR_HUMAN (6-530): 0: 744: 71.62		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		537897 KPYM_HUMAN (1-531): 0: 801: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		537898 KPYM_HUMAN (1-531): 0: 801: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		537982 KPYM_HUMAN (1-531): 0: 801: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77