HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25361076, 18239673
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001666 - response to hypoxia GO:0005634 - nucleus GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 803 Hs			1 618
+	Hs
		538220 ENPL_HUMAN (1-803): 0: 1073: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		538200 ENPL_HUMAN (1-803): 0: 1073: 100.00		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		438140 HS90B_HUMAN (75-783): 0: 997: 46.54		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		438080 HS90B_HUMAN (75-783): 0: 997: 46.54		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		431747 HS90A_HUMAN (60-783): 0: 990: 45.34		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		438074 HS90B_HUMAN (75-783): 0: 997: 46.54		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		177645 HS90A_HUMAN (60-783): 0: 990: 45.34		BIRC5_HUMAN (267-346): 2.28e-22: 95.4: 34.12
+	Dr
		223349 HS90B_DANRE (75-783): 0: 1001: 45.72		MIB1_DANRE (366-612): 9.15e-14: 77: 16.19