HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: MYLK4 (Q86YV6)
Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)
Gene: MYLK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 388
+	Hs
		538446 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT3_HUMAN (7-386): 4.81e-135: 396: 23.02
+	Hs
		538122 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT1_HUMAN (3-386): 2.96e-134: 394: 23.68
+	Hs
		538102 ENPL_HUMAN (1-803): 0: 1073: 100.00		KAPCB_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		438328 HS90B_HUMAN (75-783): 0: 997: 46.54		MYLK4_HUMAN (1-388): 3.73e-139: 403: 100.00
+	Hs
		437928 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT2_HUMAN (10-380): 4.47e-137: 401: 22.86
+	Mm
		513660 HS90B_MOUSE (75-783): 0: 998: 46.26		AKT1_MOUSE (3-386): 4.91e-135: 396: 23.68
+	Bt
		964601 HS90B_BOVIN (75-783): 0: 997: 46.68		AKT1_BOVIN (6-386): 1.66e-135: 397: 23.86
+	Hs
		438633 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT3_HUMAN (7-386): 4.81e-135: 396: 23.02
+	Hs
		437927 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT1_HUMAN (3-386): 2.96e-134: 394: 23.68
+	Hs
		438224 HS90B_HUMAN (75-783): 0: 997: 46.54		MYLK3_HUMAN (27-378): 3.38e-129: 392: 60.80
+	Hs
		438441 HS90B_HUMAN (75-783): 0: 997: 46.54		KCC1G_HUMAN (93-384): 4.51e-127: 376: 33.56
+	Hs
		438519 HS90B_HUMAN (75-783): 0: 997: 46.54		MYLK2_HUMAN (30-388): 3.9e-124: 372: 50.69
+	Hs
		437900 HS90B_HUMAN (75-783): 0: 997: 46.54		KAPCB_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		438148 HS90B_HUMAN (75-783): 0: 997: 46.54		KCC2D_HUMAN (104-370): 3.52e-124: 369: 35.06
+	Hs
		70435 HS90A_HUMAN (60-783): 0: 990: 45.34		B2RB89_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		200083 HS90B_HUMAN (75-783): 0: 997: 46.54		DAPK3_HUMAN (94-361): 2.46e-71: 232: 43.48
+	Hs
		200082 HS90A_HUMAN (60-783): 0: 990: 45.34		DAPK3_HUMAN (94-361): 2.46e-71: 232: 43.48
+	Hs
		437842 HS90B_HUMAN (75-783): 0: 997: 46.54		KPSH1_HUMAN (84-361): 1e-54: 187: 38.25
+	Hs
		438447 HS90B_HUMAN (75-783): 0: 997: 46.54		PSKH2_HUMAN (111-361): 3.66e-53: 182: 38.19
+	Hs
		438631 HS90B_HUMAN (75-783): 0: 997: 46.54		KCC2A_HUMAN (110-362): 3.53e-50: 177: 37.35