HitPredict

Interactor 1: CCNB1 (P14635)
G2/mitotic-specific cyclin-B1
Gene: CCNB1

Interactor 2: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	28514442, 33961781, 26496610, 30674583, 18471975
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0019901 - protein kinase binding GO:0044772 - mitotic cell cycle phase transition GO:0051301 - cell division GO:0061575 - cyclin-dependent protein serine/threonine kinase activator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 79
+	Hs
		538483 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188178 CCB24_ARATH (7-423): 9.76e-120: 357: 27.59		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Hs
		303840 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		895411 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	At
		1352139 CCB24_ARATH (7-423): 9.76e-120: 357: 27.59		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Hs
		303832 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	Hs
		706795 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188148 CCA23_ARATH (7-423): 4.19e-115: 346: 28.11		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Hs
		590156 CCNA2_HUMAN (9-421): 3.65e-112: 338: 29.12		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	At
		188149 CCB12_ARATH (11-422): 1.24e-112: 339: 29.66		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Hs
		590135 CCNA2_HUMAN (9-421): 3.65e-112: 338: 29.12		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		1106919 CCB12_ARATH (11-422): 1.24e-112: 339: 29.66		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		188167 CCB23_ARATH (9-422): 2.46e-111: 335: 25.58		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Dm
		540500 CCNA_DROME (1-421): 9.47e-103: 315: 25.00		Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83
+	At
		188134 CCB14_ARATH (30-424): 1.75e-102: 311: 31.66		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1324477 CCA31_ARATH (75-427): 7.25e-103: 311: 31.51		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Dm
		540479 CCNA_DROME (1-421): 9.47e-103: 315: 25.00		CKS1_DROME (4-72): 4.45e-35: 115: 78.26
+	At
		48925 CCA33_ARATH (125-426): 1.04e-100: 305: 37.22		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Sc
		594110 CG22_YEAST (5-416): 1.45e-101: 312: 30.36		CKS1_YEAST (3-73): 3.34e-32: 110: 50.00
+	Sc
		594112 CG24_YEAST (38-417): 4.54e-100: 308: 27.14		CKS1_YEAST (3-73): 3.34e-32: 110: 50.00