HitPredict

Interactor 1: CCNB1 (P14635)
G2/mitotic-specific cyclin-B1
Gene: CCNB1

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	25852190, 26186194, 28514442, 33961781, 35271311, 32707033, 36736316, 23602568, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 292
+	Hs
		538471 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		538521 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		414711 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		538497 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	Mm
		509465 CCNB1_MOUSE (1-432): 6.96e-153: 441: 84.26		CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70
+	Hs
		303829 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		625350 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Xl
		526765 CCNB1_XENLA (1-430): 1.29e-126: 373: 64.19		CDK1A_XENLA (1-289): 5.63e-134: 383: 56.01
+	Hs
		303843 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Mm
		956329 CCNA1_MOUSE (5-418): 5.26e-118: 352: 26.54		CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77
+	Gg
		533892 CCNB2_CHICK (13-430): 9.7e-121: 358: 48.57		CDK1_CHICK (1-289): 1.37e-133: 381: 56.70
+	At
		621691 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	Hs
		303821 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		414855 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	At
		1320941 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CDKD3_ARATH (2-292): 2.44e-126: 366: 47.77
+	At
		1103366 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CKB12_ARATH (1-289): 1.61e-123: 356: 50.97
+	Hs
		303844 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK17_HUMAN (1-291): 3.52e-121: 358: 55.82
+	At
		1227952 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CKB21_ARATH (1-290): 1.28e-121: 352: 48.00
+	At
		639373 CCB24_ARATH (7-423): 9.76e-120: 357: 27.59		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98
+	At
		639358 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98