HitPredict

Interactor 1: MYL6B (P14649)
Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B)
Gene: MYL6B

Interactor 2: ML12A (P19105)
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)
Gene: MYL12A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0016459 - myosin complex GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 208 Hs			1 171
+	Hs
		580632 MYL6_HUMAN (60-207): 5.77e-70: 211: 81.76		ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00
+	Hs
		159559 MYL6_HUMAN (60-207): 5.77e-70: 211: 81.76		ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37
+	Hs
		624346 MYL6_HUMAN (60-207): 5.77e-70: 211: 81.76		MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30
+	Hs
		409446 MYL1_HUMAN (49-208): 9.78e-65: 200: 69.38		ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00
+	Hs
		159536 MYL6B_HUMAN (1-208): 2.72e-52: 168: 100.00		ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37
+	Hs
		538639 MYL6B_HUMAN (1-208): 2.72e-52: 168: 100.00		MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30
+	At
		886540 CALM6_ARATH (60-207): 7.44e-67: 203: 43.62		CALM7_ARATH (97-170): 8.84e-15: 69.1: 25.68
+	Hs
		483914 MYL6_HUMAN (60-207): 5.77e-70: 211: 81.76		CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		483988 MYL6_HUMAN (60-207): 5.77e-70: 211: 81.76		CALM2_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		484091 MYL6_HUMAN (60-207): 5.77e-70: 211: 81.76		CALM3_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		409438 MYL1_HUMAN (49-208): 9.78e-65: 200: 69.38		CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		409439 MYL1_HUMAN (49-208): 9.78e-65: 200: 69.38		CALM3_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		483903 CALL3_HUMAN (60-207): 2.54e-65: 199: 44.97		CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		483976 CALL3_HUMAN (60-207): 2.54e-65: 199: 44.97		CALM2_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Ce
		585992 MLE_CAEEL (69-207): 1.46e-32: 116: 46.04		MLR1_CAEEL (23-169): 2.25e-39: 133: 49.32
+	Ce
		585996 MLE_CAEEL (69-207): 1.46e-32: 116: 46.04		MLR2_CAEEL (23-169): 1.93e-39: 133: 49.32
+	Hs
		483897 MYL6B_HUMAN (1-208): 2.72e-52: 168: 100.00		CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		483970 MYL6B_HUMAN (1-208): 2.72e-52: 168: 100.00		CALM2_HUMAN (16-92): 3.58e-09: 54.5: 24.69
+	Hs
		484054 MYL6B_HUMAN (1-208): 2.72e-52: 168: 100.00		CALM3_HUMAN (16-92): 3.58e-09: 54.5: 24.69