HitPredict

Interactor 1: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Interactor 2: CCL23 (P55773)
C-C motif chemokine 23 (CK-beta-8) (CKB-8) (Macrophage inflammatory protein 3) (MIP-3) (Myeloid progenitor inhibitory factor 1) (MPIF-1) (Small-inducible cytokine A23) [Cleaved into: CCL23(19-99); CCL23(22-99); CCL23(27-99); CCL23(30-99)]
Gene: CCL23

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1019 Hs			1 120
+	Hs
		539773 IDE_HUMAN (1-1019): 0: 1084: 100.00		CL3L1_HUMAN (1-113): 1.97e-32: 111: 39.82
+	Hs
		486219 IDE_HUMAN (1-1019): 0: 1084: 100.00		CCL3_HUMAN (1-113): 4.97e-32: 109: 39.82
+	Hs
		526554 IDE_HUMAN (1-1019): 0: 1084: 100.00		CCL4_HUMAN (1-112): 2.21e-30: 106: 36.61
+	Hs
		134740 PREP_HUMAN (91-965): 1.14e-133: 431: 13.57		CCL22_HUMAN (43-111): 1.12e-20: 81.4: 25.35