HitPredict

Interactor 1: EPOR (P14753)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Interactor 2: CISH (Q62225)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	12441334, 7796808
Identification Methods	affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 507 Mm			1 257
+	Hs
		581173 EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69		CISH_HUMAN (1-257): 1.73e-67: 211: 87.21
+	Hs
		433567 EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69		LYN_HUMAN (6-252): 1.98e-49: 171: 14.57
+	Hs
		146592 EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69		SOCS2_HUMAN (48-257): 1.58e-50: 165: 40.48
+	Mm
		540265 EPOR_MOUSE (1-507): 2.85e-136: 405: 100.00		LYN_MOUSE (6-252): 8.57e-50: 172: 14.57
+	Hs
		522759 EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69		SRC_HUMAN (17-251): 9.43e-47: 164: 14.19
+	Hs
		147386 EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69		SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14
+	Mm
		193372 EPOR_MOUSE (1-507): 2.85e-136: 405: 100.00		SOCS3_MOUSE (51-253): 2.46e-47: 158: 29.67
+	Hs
		581157 EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69		GRB2_HUMAN (34-217): 2.53e-41: 143: 15.84
+	Mm
		540268 EPOR_MOUSE (1-507): 2.85e-136: 405: 100.00		GRB2_MOUSE (34-217): 8.9e-41: 141: 15.84
+	Rn
		70070 GHR_RAT (13-485): 4.49e-85: 277: 15.60		B1WBX9_RAT (1-257): 1.12e-73: 226: 96.11
+	Hs
		581150 EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69		P85A_HUMAN (62-189): 5.55e-17: 82.2: 16.92
+	Hs
		500974 GHR_HUMAN (18-505): 2.17e-84: 275: 15.40		CISH_HUMAN (1-257): 1.73e-67: 211: 87.21
+	Mm
		540266 EPOR_MOUSE (1-507): 2.85e-136: 405: 100.00		P85A_MOUSE (62-188): 5.69e-12: 67.2: 17.05
+	Hs
		146586 GHR_HUMAN (18-505): 2.17e-84: 275: 15.40		SOCS2_HUMAN (48-257): 1.58e-50: 165: 40.48
+	Hs
		147382 GHR_HUMAN (18-505): 2.17e-84: 275: 15.40		SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14
+	Hs
		181779 GHR_HUMAN (18-505): 2.17e-84: 275: 15.40		SOCS1_HUMAN (59-257): 6.41e-44: 149: 28.36
+	Hs
		500956 GHR_HUMAN (18-505): 2.17e-84: 275: 15.40		GRB2_HUMAN (34-217): 2.53e-41: 143: 15.84
+	Hs
		146590 PRLR_HUMAN (42-460): 1.03e-70: 238: 19.03		SOCS2_HUMAN (48-257): 1.58e-50: 165: 40.48
+	Hs
		129180 GHR_HUMAN (18-505): 2.17e-84: 275: 15.40		P85B_HUMAN (73-183): 3.25e-17: 82.5: 19.82
+	Hs
		500948 GHR_HUMAN (18-505): 2.17e-84: 275: 15.40		P85A_HUMAN (62-189): 5.55e-17: 82.2: 16.92