HitPredict

Interactor 1: MMP9 (P14780)
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
Gene: MMP9

Interactor 2: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 707 Hs			1 107
+	Hs
		364037 MMP9_HUMAN (1-707): 0: 862: 100.00		CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78
+	Hs
		540419 MMP9_HUMAN (1-707): 0: 862: 100.00		CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05
+	Hs
		486175 MMP9_HUMAN (1-707): 0: 862: 100.00		IL8_HUMAN (25-107): 4.56e-25: 92: 40.00
+	Hs
		540420 MMP9_HUMAN (1-707): 0: 862: 100.00		CXCL6_HUMAN (30-104): 1.15e-24: 91.6: 40.00
+	Hs
		486190 MMP13_HUMAN (1-277): 5.97e-98: 311: 35.15		IL8_HUMAN (25-107): 4.56e-25: 92: 40.00
+	Hs
		587770 MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47		CXCL2_HUMAN (1-107): 5.5e-34: 114: 100.00
+	Hs
		372731 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		CXCL2_HUMAN (1-107): 5.5e-34: 114: 100.00
+	Hs
		587787 MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47		CXCL3_HUMAN (1-107): 9.63e-32: 109: 87.85
+	Hs
		448989 MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47		GROA_HUMAN (1-107): 2.31e-31: 108: 89.72
+	Mm
		500671 MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95		CXCL2_MOUSE (9-107): 2.87e-32: 110: 62.63
+	Hs
		364043 MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47		CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78
+	Hs
		364034 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78
+	Hs
		764724 MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47		CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05
+	Hs
		372733 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05
+	Hs
		486188 MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47		IL8_HUMAN (25-107): 4.56e-25: 92: 40.00
+	Hs
		764727 MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47		CXCL6_HUMAN (30-104): 1.15e-24: 91.6: 40.00
+	Hs
		372724 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		IL8_HUMAN (25-107): 4.56e-25: 92: 40.00
+	Mm
		522396 MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95		GROA_MOUSE (33-103): 4.04e-27: 97: 71.83
+	Hs
		372737 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		CXCL6_HUMAN (30-104): 1.15e-24: 91.6: 40.00
+	Mm
		714630 MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95		CXCL5_MOUSE (21-105): 2.52e-24: 91.3: 43.82