HitPredict

Interactor 1: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Interactor 2: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	20816854, 10602027, 21516110
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019221 - cytokine-mediated signaling pathway GO:0035723 - interleukin-15-mediated signaling pathway GO:0038110 - interleukin-2-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 794
+	Mm
		557512 IL2RB_MOUSE (1-551): 3.91e-167: 486: 56.84		STA5A_MOUSE (1-794): 0: 1043: 96.35
+	Hs
		540455 IL2RB_HUMAN (1-551): 0: 527: 100.00		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Mm
		557513 IL2RB_MOUSE (1-551): 3.91e-167: 486: 56.84		STA5B_MOUSE (1-774): 0: 985: 92.17
+	Mm
		786650 PRLR_MOUSE (6-456): 1.04e-96: 308: 14.22		STA5A_MOUSE (1-794): 0: 1043: 96.35
+	Hs
		540451 IL2RB_HUMAN (1-551): 0: 527: 100.00		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		540449 IL2RB_HUMAN (1-551): 0: 527: 100.00		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		581154 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		STA5A_HUMAN (1-794): 0: 1050: 100.00
+	Mm
		562611 GHR_MOUSE (22-522): 1.41e-61: 215: 14.69		STA5A_MOUSE (1-794): 0: 1043: 96.35
+	Hs
		500954 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		560469 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		540463 IL2RB_HUMAN (1-551): 0: 527: 100.00		STAT4_HUMAN (1-738): 0: 715: 29.34
+	Hs
		562533 IL7RA_HUMAN (92-351): 4.68e-52: 185: 16.60		STA5A_HUMAN (1-794): 0: 1050: 100.00
+	Mm
		562612 GHR_MOUSE (22-522): 1.41e-61: 215: 14.69		STA5B_MOUSE (1-774): 0: 985: 92.17
+	Hs
		500951 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Mm
		562610 GHR_MOUSE (22-522): 1.41e-61: 215: 14.69		STAT3_MOUSE (1-723): 0: 737: 29.94
+	Hs
		562532 IL7RA_HUMAN (92-351): 4.68e-52: 185: 16.60		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		786348 I13R2_HUMAN (26-261): 2.55e-51: 182: 13.75		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		562528 IL7RA_HUMAN (92-351): 4.68e-52: 185: 16.60		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Mm
		558504 IL4RA_MOUSE (1-521): 5.8e-47: 177: 16.94		STAT3_MOUSE (1-723): 0: 737: 29.94
+	Mm
		558505 IL4RA_MOUSE (1-521): 5.8e-47: 177: 16.94		STAT6_MOUSE (1-766): 0: 698: 38.69