HitPredict

Interactor 1: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10602027
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 217
+	Hs
		411578 IL2RB_HUMAN (1-551): 0: 527: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		500956 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		682260 IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		581157 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		540268 EPOR_MOUSE (7-427): 1.75e-58: 204: 19.30		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		665574 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		581163 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74
+	Hs
		500941 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		548629 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		560471 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		337360 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		665558 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		548635 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		433567 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522759 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		540265 EPOR_MOUSE (7-427): 1.75e-58: 204: 19.30		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Hs
		433265 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		665608 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		522803 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		403425 EPHB2_MOUSE (28-329): 4.33e-52: 193: 14.47		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58