HitPredict

Interactor 1: CYPH (P14832)
Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (CPH) (Cyclosporin A-binding protein) (PPI-II) (Rotamase)
Gene: CPR1

Interactor 2: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31399574, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006457 - protein folding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 162 Sc			1 705
+	Hs
		438106 PPID_HUMAN (2-162): 9.39e-87: 260: 58.58		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		438624 PPIE_HUMAN (2-161): 1.94e-87: 259: 61.25		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		431781 PPID_HUMAN (2-162): 9.39e-87: 260: 58.58		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		432365 PPIE_HUMAN (2-161): 1.94e-87: 259: 61.25		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	At
		646590 CYP40_ARATH (2-162): 9.4e-85: 254: 52.94		HS901_ARATH (3-705): 0: 993: 63.26
+	At
		878280 CYP40_ARATH (2-162): 9.4e-85: 254: 52.94		HS902_ARATH (3-705): 0: 984: 63.93
+	Sc
		543295 CYPC_YEAST (3-162): 2.46e-88: 257: 71.25		HSC82_YEAST (1-705): 0: 977: 100.00
+	Sc
		365886 CYPC_YEAST (3-162): 2.46e-88: 257: 71.25		HSP82_YEAST (1-705): 0: 968: 95.63
+	Sc
		365705 CYPH_YEAST (1-162): 2.94e-88: 256: 100.00		HSP82_YEAST (1-705): 0: 968: 95.63
+	Ca
		804532 PPID_CANAL (2-162): 1.26e-64: 203: 61.14		HSP90_CANAL (4-705): 0: 953: 82.36
+	Hs
		538104 PPIB_HUMAN (3-162): 9.69e-87: 254: 60.25		ENPL_HUMAN (3-680): 0: 893: 47.10