HitPredict

Interactor 1: SEC63 (P14906)
Protein translocation protein SEC63 (Protein NPL1) (Sec62/63 complex 73 kDa subunit)
Gene: SEC63

Interactor 2: SC61A (P32915)
Protein transport protein SEC61 (Sec61 complex subunit SEC61) (Sec61 complex subunit alpha)
Gene: SEC61

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	30682149, 37968396, 10436009, 9252322, 2000150, 11251072, 30644436, 33780447, 20378542
Identification Methods	affinity chromatography technology, protein complementation assay, biochemical
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0008320 - protein transmembrane transporter activity GO:0030867 - rough endoplasmic reticulum membrane GO:0031204 - post-translational protein targeting to membrane, translocation GO:0071256 - translocon complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 663 Sc			1 480
+	Sc
		541697 SEC63_YEAST (1-663): 0: 568: 100.00		SSH1_YEAST (1-465): 3.93e-165: 477: 32.77
+	Sc
		701521 SLH1_YEAST (222-516): 4.11e-48: 185: 10.53		SC61A_YEAST (1-480): 0: 649: 100.00
+	Hs
		1334462 SEC63_HUMAN (437-642): 1.64e-13: 76.2: 13.11		S61A2_HUMAN (3-465): 0: 683: 56.25
+	Hs
		901544 SEC63_HUMAN (437-642): 1.64e-13: 76.2: 13.11		S61A1_HUMAN (5-465): 0: 679: 56.49
+	Bt
		90458 E1B7B1_BOVIN (437-642): 1.75e-13: 75.8: 13.11		S61A1_BOVIN (3-465): 0: 679: 55.82