HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

The method score is based on:

Property	Details
Experiments	24981860, 9739078, 9348293, 37071682, 25225338, 17353931
Identification Methods	affinity chromatography technology, two hybrid, cross-linking study, reverse ras recruitment system, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001533 - cornified envelope GO:0005198 - structural molecule activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005882 - intermediate filament and 11 others more... GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0014704 - intercalated disc GO:0030057 - desmosome GO:0043588 - skin development GO:0070062 - extracellular exosome GO:0086073 - bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086083 - cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086091 - regulation of heart rate by cardiac conduction GO:0098609 - cell-cell adhesion GO:0098911 - regulation of ventricular cardiac muscle cell action potential
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	745
Hs

1	2871

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024