HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005925 - focal adhesion and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 191
+	Hs
		542173 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		542444 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		542271 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		542276 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		542258 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		542164 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436141 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		564428 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		542254 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		542370 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		717346 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		716971 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Mm
		925786 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31
+	Hs
		716931 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		716991 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		716935 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545229 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		716929 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		717184 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Mm
		677654 CTND1_MOUSE (207-730): 3.06e-94: 315: 16.42		RHOA_MOUSE (5-191): 9.99e-82: 242: 53.48