HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0045766 - positive regulation of angiogenesis and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 196
+	Hs
		542271 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		542258 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		542164 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436141 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		542276 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		542254 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		542255 PLAK_HUMAN (1-745): 0: 551: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		542173 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		716971 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		120295 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Mm
		925786 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10
+	Hs
		716935 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		716955 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545229 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		716991 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		716929 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		716931 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564428 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120321 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Mm
		677654 CTND1_MOUSE (207-730): 3.06e-94: 315: 16.42		RHOA_MOUSE (1-196): 3.27e-78: 233: 83.16