HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: PTPRK (Q15262)
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Gene: PTPRK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	8663237
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005912 - adherens junction GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 1439
+	Hs
		717099 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRK_HUMAN (26-1439): 0: 1191: 100.00
+	Hs
		576992 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRA_HUMAN (668-1438): 0: 736: 30.62
+	Hs
		542300 PLAK_HUMAN (1-745): 0: 551: 100.00		PTPRJ_HUMAN (128-1438): 3.98e-115: 396: 13.93
+	Hs
		717036 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRJ_HUMAN (128-1438): 3.98e-115: 396: 13.93
+	Hs
		717127 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRO_HUMAN (1162-1433): 5.11e-94: 333: 30.22
+	Hs
		489895 PLAK_HUMAN (1-745): 0: 551: 100.00		PTPRF_HUMAN (194-928): 2.83e-47: 188: 10.24
+	Hs
		489914 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRF_HUMAN (194-928): 2.83e-47: 188: 10.24
+	Mm
		56908 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		PTPRF_MOUSE (194-875): 1.71e-46: 186: 10.78
+	Rn
		1145481 CTNB1_RAT (1-731): 1.13e-173: 519: 67.38		PTPRF_RAT (194-875): 4.5e-46: 184: 10.78
+	Hs
		617080 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRG_HUMAN (700-1146): 9.42e-45: 180: 19.30
+	Hs
		617157 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRZ_HUMAN (898-1156): 1.17e-44: 180: 28.46
+	Mm
		472765 PLAK_MOUSE (1-745): 0: 553: 98.39		PTPRQ_MOUSE (83-889): 5.99e-20: 99.3: 11.96
+	Mm
		472764 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		PTPRQ_MOUSE (83-889): 5.99e-20: 99.3: 11.96
+	Hs
		441183 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRC_HUMAN (5-864): 7.75e-18: 92.3: 10.48
+	Mm
		660881 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		PTPRM_MOUSE (11-433): 6.65e-15: 82.7: 10.79
+	Hs
		616904 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRB_HUMAN (129-775): 1.95e-12: 74.6: 10.35
+	Dm
		578796 ARM_DROME (2-730): 6.94e-161: 488: 60.33		Q9W4F5_DROME (273-940): 5.97e-20: 99.3: 10.42
+	Dm
		90970 ARM_DROME (2-730): 6.94e-161: 488: 60.33		E1JJE4_DROME (273-940): 7.59e-20: 98.9: 10.42
+	Hs
		717247 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		PTPRU_HUMAN (3-427): 6.28e-09: 63.1: 10.79
+	Dm
		561758 ARM_DROME (2-730): 6.94e-161: 488: 60.33		PTP69_DROME (1-463): 1.18e-13: 78.5: 6.97