HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	25900982, 10803460, 37689310
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 605
+	Hs
		717449 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Mm
		970129 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		717413 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		239228 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		542400 PLAK_HUMAN (1-745): 0: 551: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		717264 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		853759 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Xl
		1193353 Q7ZX35_XENLA (1-740): 2.45e-173: 518: 67.51		TRCB_XENLA (383-604): 1.87e-60: 211: 28.00
+	Hs
		542260 PLAK_HUMAN (1-745): 0: 551: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		716939 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		853750 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Dm
		578711 ARM_DROME (2-730): 6.94e-161: 488: 60.33		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37
+	Hs
		245567 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		TBL1X_HUMAN (501-605): 3.8e-15: 80.4: 19.13
+	Hs
		717329 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		TBL1R_HUMAN (501-605): 3.85e-15: 80.4: 16.67
+	Hs
		239187 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Ce
		1000138 BAR1_CAEEL (120-658): 1.54e-85: 289: 24.27		LIN23_CAEEL (383-605): 1.08e-60: 215: 27.88
+	Hs
		131484 IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		239105 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		209411 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47
+	Hs
		209410 IMA1_HUMAN (270-664): 6.19e-48: 179: 14.32		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47