HitPredict

Interactor 1: ETS2 (P15036)
Protein C-ets-2
Gene: ETS2

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.684

Property	Details
Experiments	25117710, 26496610, 26871468
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 469 Hs			1 731
+	Hs
		542044 ETS1_HUMAN (60-469): 1.14e-146: 427: 55.08		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		840440 ETV1_HUMAN (173-453): 1.76e-50: 180: 25.57		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		781148 ETV5_HUMAN (205-453): 6.65e-50: 179: 28.11		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		794556 ETV4_HUMAN (166-469): 8.28e-48: 173: 27.25		COP1_HUMAN (1-731): 0: 540: 100.00
+	Mm
		1321861 ETV5_MOUSE (186-453): 4.71e-49: 177: 24.49		COP1_MOUSE (1-731): 3.36e-168: 503: 96.86
+	Hs
		781648 ETV6_HUMAN (69-468): 3.67e-108: 330: 22.43		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67
+	Mm
		785339 ELK1_MOUSE (362-447): 6.98e-39: 147: 60.92		FBXW7_MOUSE (452-730): 4.71e-69: 242: 17.15
+	Hs
		1074807 ELF4_HUMAN (205-467): 1.22e-58: 205: 26.22		TAF5_HUMAN (525-731): 1.71e-35: 146: 17.79
+	Hs
		1074784 ELF2_HUMAN (179-456): 2.67e-54: 192: 23.39		TAF5_HUMAN (525-731): 1.71e-35: 146: 17.79
+	Mm
		785432 ELK3_MOUSE (363-443): 1.03e-20: 95.9: 60.49		FBXW7_MOUSE (452-730): 4.71e-69: 242: 17.15
+	Hs
		692139 ELF1_HUMAN (200-454): 5.62e-49: 179: 24.81		TAF5_HUMAN (525-731): 1.71e-35: 146: 17.79
+	Hs
		1074806 FEV_HUMAN (342-454): 2.11e-48: 167: 57.52		TAF5_HUMAN (525-731): 1.71e-35: 146: 17.79
+	Hs
		267789 ELF4_HUMAN (205-467): 1.22e-58: 205: 26.22		TAF5L_HUMAN (486-667): 2.48e-11: 68.9: 29.57
+	Hs
		692171 ELF1_HUMAN (200-454): 5.62e-49: 179: 24.81		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67
+	Hs
		785364 ELK3_HUMAN (379-443): 3.28e-17: 85.1: 60.00		TAF5_HUMAN (525-731): 1.71e-35: 146: 17.79
+	Mm
		1161092 ELF5_MOUSE (68-184): 1.09e-12: 69.6: 18.49		SNR40_MOUSE (587-730): 9.62e-27: 114: 19.18
+	Mm
		903675 ELF5_MOUSE (68-184): 1.09e-12: 69.6: 18.49		WDR5_MOUSE (632-730): 5.38e-16: 81.8: 18.18