HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: FUS3 (P16892)
Mitogen-activated protein kinase FUS3 (MAP kinase FUS3) (EC 2.7.11.24)
Gene: FUS3

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16319894
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005739 - mitochondrion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 353
+	Mm
		513710 HS90B_MOUSE (5-705): 0: 1025: 61.57		MK07_MOUSE (5-351): 3.06e-139: 416: 47.14
+	Hs
		438129 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK07_HUMAN (5-351): 2.76e-139: 416: 47.43
+	Rn
		92848 HS90B_RAT (5-705): 0: 1025: 61.57		E9PTH2_RAT (5-351): 1e-135: 407: 47.43
+	Hs
		431807 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK07_HUMAN (5-351): 2.76e-139: 416: 47.43
+	Rn
		600340 HS90B_RAT (5-705): 0: 1025: 61.57		MK03_RAT (3-350): 2.34e-139: 402: 49.43
+	Hs
		437913 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK03_HUMAN (1-350): 1.8e-139: 402: 49.14
+	Rn
		600383 HS90A_RAT (4-705): 0: 1014: 60.59		MK03_RAT (3-350): 2.34e-139: 402: 49.43
+	Hs
		431555 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK03_HUMAN (1-350): 1.8e-139: 402: 49.14
+	Mm
		432433 HS90A_MOUSE (4-705): 0: 1012: 60.59		MK03_MOUSE (3-350): 2.24e-139: 402: 49.43
+	Mm
		432419 HS90A_MOUSE (4-705): 0: 1012: 60.59		MK01_MOUSE (1-350): 2.55e-139: 401: 49.71
+	Hs
		437908 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK2_HUMAN (10-315): 1.9e-135: 389: 36.45
+	Hs
		438075 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK3_HUMAN (10-323): 2.24e-134: 386: 36.79
+	Hs
		431549 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK2_HUMAN (10-315): 1.9e-135: 389: 36.45
+	Hs
		431741 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK3_HUMAN (10-323): 2.24e-134: 386: 36.79
+	Sc
		543393 HSC82_YEAST (1-705): 0: 977: 100.00		HOG1_YEAST (5-352): 1.76e-140: 407: 44.13
+	At
		850798 HS903_ARATH (3-705): 0: 984: 63.37		MPK10_ARATH (7-353): 9.9e-136: 393: 45.71
+	Sc
		365984 HSP82_YEAST (1-705): 0: 968: 95.63		HOG1_YEAST (5-352): 1.76e-140: 407: 44.13
+	Sc
		365698 HSP82_YEAST (1-705): 0: 968: 95.63		KSS1_YEAST (1-352): 8.37e-135: 390: 52.45
+	Hs
		438208 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK14_HUMAN (4-353): 1.01e-102: 308: 44.89
+	Hs
		431896 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK14_HUMAN (4-353): 1.01e-102: 308: 44.89