HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: FKBP (P20081)
FK506-binding protein 1 (FKBP) (12-kDa cytosolic FK506-binding protein) (FKBP-12) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (EC 5.2.1.8) (Rapamycin-binding protein)
Gene: FPR1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	11805837, 31399574
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~HSP90
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0006457 - protein folding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 114
+	Hs
		431721 HS90A_HUMAN (4-705): 0: 1013: 60.67		FKB1A_HUMAN (8-114): 5.84e-54: 165: 57.01
+	Hs
		259915 HS90B_HUMAN (5-705): 0: 1022: 61.15		FKBP6_HUMAN (1-113): 4.82e-42: 142: 33.33
+	Hs
		111930 K9JA46_HUMAN (4-705): 0: 1013: 60.67		FKBP6_HUMAN (1-113): 4.82e-42: 142: 33.33
+	Hs
		259914 HS90A_HUMAN (4-705): 0: 1013: 60.67		FKBP6_HUMAN (1-113): 4.82e-42: 142: 33.33
+	Sc
		365771 HSP82_YEAST (1-705): 0: 968: 95.63		FKBP_YEAST (1-114): 1.68e-53: 164: 100.00
+	Sc
		543720 HSC82_YEAST (1-705): 0: 977: 100.00		FKBP3_YEAST (2-113): 1.66e-41: 142: 46.43
+	Sc
		544446 HSC82_YEAST (1-705): 0: 977: 100.00		FKBP4_YEAST (2-113): 1.05e-41: 142: 42.86
+	Sc
		366281 HSP82_YEAST (1-705): 0: 968: 95.63		FKBP3_YEAST (2-113): 1.66e-41: 142: 46.43
+	Hs
		438089 HS90B_HUMAN (5-705): 0: 1022: 61.15		FKBP4_HUMAN (1-114): 9.7e-18: 79: 22.88
+	Hs
		438136 HS90B_HUMAN (5-705): 0: 1022: 61.15		FKBP5_HUMAN (6-114): 2.72e-16: 74.8: 27.93
+	Hs
		111936 K9JA46_HUMAN (4-705): 0: 1013: 60.67		FKBP4_HUMAN (1-114): 9.7e-18: 79: 22.88
+	Hs
		431755 HS90A_HUMAN (4-705): 0: 1013: 60.67		FKBP4_HUMAN (1-114): 9.7e-18: 79: 22.88
+	Mm
		432409 HS90A_MOUSE (4-705): 0: 1012: 60.59		FKBP4_MOUSE (1-114): 9.78e-18: 79: 22.03
+	Hs
		111937 K9JA46_HUMAN (4-705): 0: 1013: 60.67		FKBP5_HUMAN (6-114): 2.72e-16: 74.8: 27.93
+	Hs
		431818 HS90A_HUMAN (4-705): 0: 1013: 60.67		FKBP5_HUMAN (6-114): 2.72e-16: 74.8: 27.93
+	At
		646588 HS901_ARATH (3-705): 0: 993: 63.26		FKB62_ARATH (6-112): 1.73e-20: 86.7: 25.89
+	Ce
		220015 HSP90_CAEEL (3-705): 0: 947: 61.39		O45418_CAEEL (1-114): 2.77e-13: 66.3: 26.89