HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: TAH1 (P25638)
TPR repeat-containing protein associated with Hsp90
Gene: TAH1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	33826901, 20663878, 19536198
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000492 - box C/D snoRNP assembly GO:0005737 - cytoplasm GO:0006457 - protein folding GO:0050821 - protein stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 111
+	Hs
		213454 HS90B_HUMAN (5-705): 0: 1022: 61.15		SGTA_HUMAN (2-111): 3.61e-35: 124: 28.83
+	Mm
		513680 HS90B_MOUSE (5-705): 0: 1025: 61.57		PPP5_MOUSE (1-107): 3.3e-33: 121: 20.37
+	Hs
		438021 HS90B_HUMAN (5-705): 0: 1022: 61.15		PPP5_HUMAN (1-107): 1.08e-32: 120: 20.37
+	Mm
		513709 HS90B_MOUSE (5-705): 0: 1025: 61.57		CHIP_MOUSE (2-104): 7.88e-32: 115: 27.89
+	Hs
		213451 HS90A_HUMAN (4-705): 0: 1013: 60.67		SGTA_HUMAN (2-111): 3.61e-35: 124: 28.83
+	Hs
		438621 HS90B_HUMAN (5-705): 0: 1022: 61.15		CHIP_HUMAN (2-104): 1.17e-31: 114: 27.89
+	Hs
		111935 K9JA46_HUMAN (4-705): 0: 1013: 60.67		PPP5_HUMAN (1-107): 1.08e-32: 120: 20.37
+	Hs
		431681 HS90A_HUMAN (4-705): 0: 1013: 60.67		PPP5_HUMAN (1-107): 1.08e-32: 120: 20.37
+	Mm
		432427 HS90A_MOUSE (4-705): 0: 1012: 60.59		PPP5_MOUSE (1-107): 3.3e-33: 121: 20.37
+	Hs
		432363 HS90A_HUMAN (4-705): 0: 1013: 60.67		CHIP_HUMAN (2-104): 1.17e-31: 114: 27.89
+	Hs
		438533 HS90B_HUMAN (5-705): 0: 1022: 61.15		RPAP3_HUMAN (2-107): 8.47e-27: 104: 24.30
+	At
		646594 HS901_ARATH (3-705): 0: 993: 63.26		OE64C_ARATH (2-107): 1.49e-35: 129: 25.23
+	At
		137805 HS904_ARATH (3-705): 0: 991: 63.37		OE64C_ARATH (2-107): 1.49e-35: 129: 25.23
+	At
		99226 HS901_ARATH (3-705): 0: 993: 63.26		OE64M_ARATH (1-109): 2.05e-34: 125: 22.73
+	Hs
		432268 HS90A_HUMAN (4-705): 0: 1013: 60.67		RPAP3_HUMAN (2-107): 8.47e-27: 104: 24.30
+	At
		99224 HS904_ARATH (3-705): 0: 991: 63.37		OE64M_ARATH (1-109): 2.05e-34: 125: 22.73
+	Hs
		437930 HS90B_HUMAN (5-705): 0: 1022: 61.15		STIP1_HUMAN (4-110): 5.68e-09: 54: 17.16
+	Hs
		111934 K9JA46_HUMAN (4-705): 0: 1013: 60.67		STIP1_HUMAN (4-110): 5.68e-09: 54: 17.16
+	Hs
		431574 HS90A_HUMAN (4-705): 0: 1013: 60.67		STIP1_HUMAN (4-110): 5.68e-09: 54: 17.16
+	Dm
		365481 HSP83_DROME (3-705): 0: 999: 59.58		Q9VPN5_DROME (5-79): 1.21e-09: 55.8: 33.33