HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: MCM4 (P30665)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54)
Gene: MCM4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37295430
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0016887 - ATP hydrolysis activity
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 933
+	Hs
		437993 HS90B_HUMAN (5-705): 0: 1022: 61.15		MCM2_HUMAN (31-902): 0: 714: 26.03
+	Hs
		431652 HS90A_HUMAN (4-705): 0: 1013: 60.67		MCM2_HUMAN (31-902): 0: 714: 26.03
+	Hs
		437934 HS90B_HUMAN (5-705): 0: 1022: 61.15		MCM5_HUMAN (155-909): 0: 703: 28.42
+	Hs
		431580 HS90A_HUMAN (4-705): 0: 1013: 60.67		MCM5_HUMAN (155-909): 0: 703: 28.42
+	Sc
		544103 HSC82_YEAST (1-705): 0: 977: 100.00		MCM6_YEAST (106-930): 0: 696: 23.84
+	Hs
		437935 HS90B_HUMAN (5-705): 0: 1022: 61.15		MCM7_HUMAN (186-904): 0: 646: 29.50
+	Hs
		431581 HS90A_HUMAN (4-705): 0: 1013: 60.67		MCM7_HUMAN (186-904): 0: 646: 29.50
+	Sc
		365929 HSP82_YEAST (1-705): 0: 968: 95.63		MCM2_YEAST (23-849): 0: 677: 25.49
+	Hs
		538153 ENPL_HUMAN (3-680): 0: 893: 47.10		MCM2_HUMAN (31-902): 0: 714: 26.03
+	Ca
		804478 HSP90_CANAL (4-705): 0: 953: 82.36		Q59P49_CANAL (183-926): 0: 646: 30.45
+	Sc
		543605 HSC82_YEAST (1-705): 0: 977: 100.00		MCM7_YEAST (314-863): 6.73e-96: 322: 39.04
+	Sc
		366169 HSP82_YEAST (1-705): 0: 968: 95.63		MCM7_YEAST (314-863): 6.73e-96: 322: 39.04