HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: XPO1 (P30822)
Exportin-1 (Chromosome region maintenance protein 1) (Karyopherin-124)
Gene: CRM1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	16429126, 31399574, 37295430
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 1084
+	Hs
		162346 HS90B_HUMAN (5-705): 0: 1022: 61.15		XPO1_HUMAN (3-1084): 0: 854: 46.40
+	Hs
		162341 HS90A_HUMAN (4-705): 0: 1013: 60.67		XPO1_HUMAN (3-1084): 0: 854: 46.40
+	Sc
		365936 HSP82_YEAST (1-705): 0: 968: 95.63		XPO1_YEAST (1-1084): 0: 833: 100.00
+	Ca
		804502 HSP90_CANAL (4-705): 0: 953: 82.36		XPOT_CANAL (25-1040): 6.8e-84: 296: 12.79
+	Sc
		367155 HSP82_YEAST (1-705): 0: 968: 95.63		MTR10_YEAST (25-890): 2.39e-75: 270: 14.40
+	Sc
		543478 HSC82_YEAST (1-705): 0: 977: 100.00		XPOT_YEAST (13-523): 8.56e-11: 68.3: 14.31
+	Sc
		366600 HSP82_YEAST (1-705): 0: 968: 95.63		MSN5_YEAST (25-223): 1.76e-10: 67.5: 17.01