HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: HOG1 (P32485)
Mitogen-activated protein kinase HOG1 (MAP kinase HOG1) (EC 2.7.11.24) (High osmolarity glycerol response protein 1)
Gene: HOG1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31399574, 37968396
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 435
+	Hs
		437908 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK2_HUMAN (20-308): 5.17e-152: 434: 36.95
+	Mm
		513710 HS90B_MOUSE (5-705): 0: 1025: 61.57		MK07_MOUSE (8-380): 3.41e-141: 424: 41.97
+	Hs
		431549 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK2_HUMAN (20-308): 5.17e-152: 434: 36.95
+	Hs
		438129 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK07_HUMAN (8-380): 1.96e-141: 425: 41.97
+	Sc
		365984 HSP82_YEAST (1-705): 0: 968: 95.63		HOG1_YEAST (1-435): 2.33e-166: 476: 100.00
+	Hs
		437913 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK03_HUMAN (12-345): 2.48e-144: 418: 46.51
+	Rn
		92848 HS90B_RAT (5-705): 0: 1025: 61.57		E9PTH2_RAT (9-428): 2.01e-137: 415: 37.41
+	Hs
		431807 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK07_HUMAN (8-380): 1.96e-141: 425: 41.97
+	Hs
		438075 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK3_HUMAN (20-324): 1.29e-142: 410: 36.66
+	Hs
		431555 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK03_HUMAN (12-345): 2.48e-144: 418: 46.51
+	Hs
		438208 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK14_HUMAN (3-352): 7.57e-141: 408: 50.42
+	Rn
		600340 HS90B_RAT (5-705): 0: 1025: 61.57		MK03_RAT (14-351): 2.43e-137: 400: 45.98
+	Hs
		431741 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK3_HUMAN (20-324): 1.29e-142: 410: 36.66
+	Hs
		173815 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK13_HUMAN (1-352): 3.3e-137: 399: 43.98
+	Hs
		431896 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK14_HUMAN (3-352): 7.57e-141: 408: 50.42
+	Mm
		432419 HS90A_MOUSE (4-705): 0: 1012: 60.59		MK01_MOUSE (10-349): 2.16e-138: 402: 47.14
+	Rn
		600383 HS90A_RAT (4-705): 0: 1014: 60.59		MK03_RAT (14-351): 2.43e-137: 400: 45.98
+	Hs
		173814 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK13_HUMAN (1-352): 3.3e-137: 399: 43.98
+	Mm
		432433 HS90A_MOUSE (4-705): 0: 1012: 60.59		MK03_MOUSE (14-349): 3.3e-137: 400: 46.24
+	At
		850798 HS903_ARATH (3-705): 0: 984: 63.37		MPK10_ARATH (1-350): 1.14e-141: 411: 44.97