HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: HSP7F (P32589)
Heat shock protein homolog SSE1 (Chaperone protein MSI3)
Gene: SSE1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31399574, 37295430, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding GO:0140662 - ATP-dependent protein folding chaperone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 693
+	Sc
		543414 HSC82_YEAST (1-705): 0: 977: 100.00		HSP79_YEAST (1-677): 0: 992: 77.11
+	Sc
		366001 HSP82_YEAST (1-705): 0: 968: 95.63		HSP79_YEAST (1-677): 0: 992: 77.11
+	Hs
		437835 HS90B_HUMAN (5-705): 0: 1022: 61.15		HSP7C_HUMAN (2-645): 0: 851: 27.04
+	Hs
		431469 HS90A_HUMAN (4-705): 0: 1013: 60.67		HSP7C_HUMAN (2-645): 0: 851: 27.04
+	Mm
		513655 HS90B_MOUSE (5-705): 0: 1025: 61.57		HS71B_MOUSE (3-643): 0: 839: 27.47
+	Hs
		431582 HS90A_HUMAN (4-705): 0: 1013: 60.67		HS71L_HUMAN (2-646): 0: 848: 26.69
+	Hs
		431508 HS90A_HUMAN (4-705): 0: 1013: 60.67		HSP76_HUMAN (4-643): 0: 842: 26.28
+	Hs
		431690 HS90A_HUMAN (4-705): 0: 1013: 60.67		HSP72_HUMAN (2-644): 0: 840: 27.08
+	Sc
		366000 HSP82_YEAST (1-705): 0: 968: 95.63		HSP7F_YEAST (1-693): 0: 829: 100.00
+	Ce
		450532 HSP90_CAEEL (3-705): 0: 947: 61.39		HSP1_CAEEL (4-645): 0: 838: 27.12
+	Hs
		437936 HS90B_HUMAN (5-705): 0: 1022: 61.15		HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47
+	Hs
		438404 HS90B_HUMAN (5-705): 0: 1022: 61.15		HS105_HUMAN (6-687): 1.23e-133: 416: 36.05
+	Hs
		431583 HS90A_HUMAN (4-705): 0: 1013: 60.67		HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47
+	Hs
		432118 HS90A_HUMAN (4-705): 0: 1013: 60.67		HS105_HUMAN (6-687): 1.23e-133: 416: 36.05
+	Sc
		449886 HSC82_YEAST (1-705): 0: 977: 100.00		HSP73_YEAST (1-642): 5.45e-72: 247: 28.33
+	Sc
		493099 HSC82_YEAST (1-705): 0: 977: 100.00		HSP72_YEAST (1-382): 1.15e-71: 246: 36.82
+	Sc
		490214 HSC82_YEAST (1-705): 0: 977: 100.00		HSP71_YEAST (1-382): 7.01e-71: 244: 36.55
+	Sc
		365611 HSP82_YEAST (1-705): 0: 968: 95.63		HSP73_YEAST (1-642): 5.45e-72: 247: 28.33
+	Sc
		365658 HSP82_YEAST (1-705): 0: 968: 95.63		HSP72_YEAST (1-382): 1.15e-71: 246: 36.82
+	Sc
		365657 HSP82_YEAST (1-705): 0: 968: 95.63		HSP71_YEAST (1-382): 7.01e-71: 244: 36.55