HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: RCK1 (P38622)
Serine/threonine-protein kinase RCK1 (EC 2.7.11.1)
Gene: RCK1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	19536198
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 512
+	Hs
		437928 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT2_HUMAN (9-463): 3.75e-131: 391: 18.84
+	Mm
		513660 HS90B_MOUSE (5-705): 0: 1025: 61.57		AKT1_MOUSE (8-465): 2.39e-128: 384: 18.76
+	Hs
		438633 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT3_HUMAN (9-488): 1.98e-129: 386: 19.02
+	Hs
		437907 HS90B_HUMAN (5-705): 0: 1022: 61.15		KPCL_HUMAN (79-476): 3.32e-126: 385: 19.51
+	Hs
		438085 HS90B_HUMAN (5-705): 0: 1022: 61.15		KPCE_HUMAN (18-473): 4.29e-125: 384: 18.76
+	Hs
		437927 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT1_HUMAN (8-465): 6.76e-128: 382: 18.55
+	Bt
		964601 HS90B_BOVIN (5-705): 0: 1022: 61.15		AKT1_BOVIN (8-466): 6.34e-128: 382: 18.94
+	Rn
		812703 HS90A_RAT (4-705): 0: 1014: 60.59		AKT1_RAT (8-465): 8.49e-128: 382: 18.34
+	Hs
		437900 HS90B_HUMAN (5-705): 0: 1022: 61.15		KAPCB_HUMAN (81-467): 8.84e-126: 372: 22.19
+	Hs
		437870 HS90B_HUMAN (5-705): 0: 1022: 61.15		KAPCA_HUMAN (81-467): 3.15e-125: 371: 22.70
+	Hs
		438585 HS90B_HUMAN (5-705): 0: 1022: 61.15		KS6B2_HUMAN (106-475): 1.17e-122: 369: 23.55
+	Hs
		70435 HS90A_HUMAN (4-705): 0: 1013: 60.67		B2RB89_HUMAN (81-467): 8.84e-126: 372: 22.19
+	Hs
		437898 HS90B_HUMAN (5-705): 0: 1022: 61.15		KAPCG_HUMAN (109-455): 6.85e-119: 355: 25.56
+	Hs
		438631 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2A_HUMAN (119-481): 1.45e-111: 340: 29.63
+	Hs
		438441 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC1G_HUMAN (101-444): 2.62e-109: 335: 36.05
+	Hs
		438148 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2D_HUMAN (119-481): 7.09e-109: 334: 29.89
+	Hs
		438011 HS90B_HUMAN (5-705): 0: 1022: 61.15		KS6A3_HUMAN (41-424): 3.95e-101: 322: 23.10
+	Hs
		438210 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC4_HUMAN (121-414): 5.86e-45: 166: 34.34
+	Hs
		438146 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2B_HUMAN (121-425): 1.71e-41: 159: 32.51
+	Hs
		437842 HS90B_HUMAN (5-705): 0: 1022: 61.15		KPSH1_HUMAN (121-456): 2.2e-40: 152: 32.06