HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: KIC1 (P38692)
Serine/threonine-protein kinase KIC1 (EC 2.7.11.1) (Kinase that interacts with CDC31) (N-rich kinase 1)
Gene: KIC1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	9813095, 37295430
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 1080
+	Hs
		438348 HS90B_HUMAN (5-705): 0: 1022: 61.15		MINK1_HUMAN (1-941): 2.9e-137: 449: 20.55
+	Hs
		432054 HS90A_HUMAN (4-705): 0: 1013: 60.67		MINK1_HUMAN (1-941): 2.9e-137: 449: 20.55
+	Mm
		250790 HS90A_MOUSE (4-705): 0: 1012: 60.59		ULK1_MOUSE (21-748): 1.98e-137: 443: 21.16
+	Hs
		438641 HS90B_HUMAN (5-705): 0: 1022: 61.15		SIK3_HUMAN (4-881): 3.2e-131: 432: 14.16
+	Hs
		432384 HS90A_HUMAN (4-705): 0: 1013: 60.67		SIK3_HUMAN (4-881): 3.2e-131: 432: 14.16
+	Hs
		131545 HS90B_HUMAN (5-705): 0: 1022: 61.15		STK25_HUMAN (17-322): 3.57e-120: 377: 46.41
+	Hs
		131544 HS90A_HUMAN (4-705): 0: 1013: 60.67		STK25_HUMAN (17-322): 3.57e-120: 377: 46.41
+	Zm
		27339 A0A1D6LMW9_MAIZE (2-680): 0: 834: 47.53		A0A1D6JGM5_MAIZE (25-944): 3.87e-142: 463: 16.82
+	Zm
		24080 A0A1D6LMW9_MAIZE (2-680): 0: 834: 47.53		A0A1D6ICZ3_MAIZE (10-437): 6.78e-136: 423: 24.11
+	Hs
		324721 HS90B_HUMAN (5-705): 0: 1022: 61.15		M4K4_HUMAN (18-277): 1.26e-52: 203: 44.32
+	Hs
		431792 HS90A_HUMAN (4-705): 0: 1013: 60.67		STK4_HUMAN (22-308): 5.67e-57: 207: 38.97
+	Hs
		324718 HS90A_HUMAN (4-705): 0: 1013: 60.67		M4K4_HUMAN (18-277): 1.26e-52: 203: 44.32