HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: TOS3 (P43637)
Serine/threonine-protein kinase TOS3 (EC 2.7.11.1) (Target of SBF protein 3)
Gene: TOS3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	19536198
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 560
+	Hs
		438147 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2G_HUMAN (41-552): 8.56e-127: 384: 19.12
+	Hs
		438148 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2D_HUMAN (38-552): 5.1e-127: 383: 20.45
+	Hs
		438631 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2A_HUMAN (41-500): 8.89e-126: 379: 20.65
+	Hs
		431826 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC2G_HUMAN (41-552): 8.56e-127: 384: 19.12
+	Hs
		431827 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC2D_HUMAN (38-552): 5.1e-127: 383: 20.45
+	Hs
		432373 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC2A_HUMAN (41-500): 8.89e-126: 379: 20.65
+	Sc
		543735 HSC82_YEAST (1-705): 0: 977: 100.00		SAK1_YEAST (26-344): 9.94e-90: 301: 50.88
+	Zm
		24080 A0A1D6LMW9_MAIZE (2-680): 0: 834: 47.53		A0A1D6ICZ3_MAIZE (6-510): 7.01e-129: 389: 18.00
+	Zm
		35496 A0A1D6LMW9_MAIZE (2-680): 0: 834: 47.53		A0A1D6QH07_MAIZE (38-524): 2.11e-129: 387: 20.40
+	Hs
		438451 HS90B_HUMAN (5-705): 0: 1022: 61.15		KKCC2_HUMAN (47-348): 4.07e-51: 186: 34.80
+	Hs
		438353 HS90B_HUMAN (5-705): 0: 1022: 61.15		KKCC1_HUMAN (47-349): 7.29e-49: 178: 36.56
+	Hs
		432178 HS90A_HUMAN (4-705): 0: 1013: 60.67		KKCC2_HUMAN (47-348): 4.07e-51: 186: 34.80
+	Hs
		432059 HS90A_HUMAN (4-705): 0: 1013: 60.67		KKCC1_HUMAN (47-349): 7.29e-49: 178: 36.56
+	Hs
		438202 HS90B_HUMAN (5-705): 0: 1022: 61.15		STK11_HUMAN (28-343): 4.14e-35: 139: 31.86
+	Hs
		431887 HS90A_HUMAN (4-705): 0: 1013: 60.67		STK11_HUMAN (28-343): 4.14e-35: 139: 31.86