HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: MTR4 (P47047)
ATP-dependent RNA helicase DOB1 (EC 3.6.4.13) (mRNA transport regulator MTR4)
Gene: MTR4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31399574, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016887 - ATP hydrolysis activity
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 1073
+	Hs
		431623 HS90A_HUMAN (4-705): 0: 1013: 60.67		MTREX_HUMAN (51-1073): 0: 797: 51.42
+	Sc
		366528 HSP82_YEAST (1-705): 0: 968: 95.63		MTR4_YEAST (1-1073): 0: 819: 100.00
+	Sc
		543515 HSC82_YEAST (1-705): 0: 977: 100.00		SKI2_YEAST (2-1073): 0: 584: 32.66
+	Sc
		366092 HSP82_YEAST (1-705): 0: 968: 95.63		SKI2_YEAST (2-1073): 0: 584: 32.66
+	Hs
		272010 HS90A_HUMAN (4-705): 0: 1013: 60.67		U520_HUMAN (98-698): 2.82e-85: 306: 18.04
+	Sc
		365837 HSP82_YEAST (1-705): 0: 968: 95.63		DBP2_YEAST (23-583): 3.84e-93: 309: 11.68
+	Sc
		544154 HSC82_YEAST (1-705): 0: 977: 100.00		SLH1_YEAST (128-685): 3.71e-80: 290: 18.70
+	Sc
		366656 HSP82_YEAST (1-705): 0: 968: 95.63		SLH1_YEAST (128-685): 3.71e-80: 290: 18.70
+	Hs
		538314 ENPL_HUMAN (3-680): 0: 893: 47.10		ASCC3_HUMAN (46-735): 4.58e-93: 329: 17.79
+	Sp
		784800 HSP90_SCHPO (4-705): 0: 945: 71.69		BRR2_SCHPO (128-692): 1.86e-50: 197: 16.07
+	Sc
		366012 HSP82_YEAST (1-705): 0: 968: 95.63		BRR2_YEAST (111-872): 7.23e-33: 140: 14.04
+	Hs
		432041 HS90A_HUMAN (4-705): 0: 1013: 60.67		DDX60_HUMAN (134-306): 8.62e-11: 68.6: 29.26