HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: YMZ2 (Q03177)
WD repeat-containing protein YMR102C
Gene: YMR102C

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	37295430, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 834
+	Sc
		366786 HSP82_YEAST (1-705): 0: 968: 95.63		YMZ2_YEAST (1-834): 5.72e-168: 509: 98.44
+	Sc
		365957 HSP82_YEAST (1-705): 0: 968: 95.63		DGR2_YEAST (15-834): 1.1e-109: 357: 35.78
+	Mm
		1174808 Q71LX8_MOUSE (5-705): 0: 1025: 61.57		AHI1_MOUSE (271-509): 1.03e-61: 228: 21.95
+	Mm
		513697 HS90B_MOUSE (5-705): 0: 1025: 61.57		AHI1_MOUSE (271-509): 1.03e-61: 228: 21.95
+	Mm
		432449 HS90A_MOUSE (4-705): 0: 1012: 60.59		AHI1_MOUSE (271-509): 1.03e-61: 228: 21.95
+	Hs
		152851 HS90A_HUMAN (4-705): 0: 1013: 60.67		APAF_HUMAN (305-792): 3.52e-58: 218: 10.50
+	Hs
		152853 ENPL_HUMAN (3-680): 0: 893: 47.10		APAF_HUMAN (305-792): 3.52e-58: 218: 10.50
+	Hs
		438057 HS90B_HUMAN (5-705): 0: 1022: 61.15		GBB2_HUMAN (412-677): 3.01e-17: 86: 10.37
+	Cr
		65491 A8J1U1_CHLRE (4-705): 0: 1002: 63.17		MUT11_CHLRE (233-507): 8.71e-24: 106: 17.77
+	Hs
		438414 HS90B_HUMAN (5-705): 0: 1022: 61.15		FBXW7_HUMAN (89-300): 2.7e-13: 75.6: 8.76
+	Hs
		437971 HS90B_HUMAN (5-705): 0: 1022: 61.15		LIS1_HUMAN (569-810): 4.8e-12: 70.9: 11.81
+	Hs
		438048 HS90B_HUMAN (5-705): 0: 1022: 61.15		WDR5_HUMAN (577-757): 3.26e-12: 70.5: 10.88
+	Hs
		432132 HS90A_HUMAN (4-705): 0: 1013: 60.67		FBXW7_HUMAN (89-300): 2.7e-13: 75.6: 8.76
+	Hs
		431630 HS90A_HUMAN (4-705): 0: 1013: 60.67		LIS1_HUMAN (569-810): 4.8e-12: 70.9: 11.81
+	Sc
		543602 HSC82_YEAST (1-705): 0: 977: 100.00		TAF5_YEAST (273-509): 2.17e-11: 69.9: 15.18
+	Sc
		366167 HSP82_YEAST (1-705): 0: 968: 95.63		TAF5_YEAST (273-509): 2.17e-11: 69.9: 15.18
+	Ca
		483034 HSP90_CANAL (4-705): 0: 953: 82.36		TUP1_CANAL (261-505): 7.92e-12: 70.7: 14.61
+	Hs
		538344 ENPL_HUMAN (3-680): 0: 893: 47.10		FBXW7_HUMAN (89-300): 2.7e-13: 75.6: 8.76
+	Hs
		538141 ENPL_HUMAN (3-680): 0: 893: 47.10		LIS1_HUMAN (569-810): 4.8e-12: 70.9: 11.81
+	Hs
		538184 ENPL_HUMAN (3-680): 0: 893: 47.10		WDR5_HUMAN (577-757): 3.26e-12: 70.5: 10.88