HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: RUVB2 (Q12464)
RuvB-like protein 2 (RUVBL2) (EC 3.6.4.12) (TIP49-homology protein 2) (TIP49b homolog)
Gene: RVB2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	16429126, 26831523, 31399574
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000492 - box C/D snoRNP assembly GO:0005524 - ATP binding GO:0016887 - ATP hydrolysis activity GO:0050821 - protein stabilization
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 471
+	Hs
		438632 HS90B_HUMAN (5-705): 0: 1022: 61.15		RUVB2_HUMAN (4-451): 0: 680: 68.15
+	Hs
		432374 HS90A_HUMAN (4-705): 0: 1013: 60.67		RUVB2_HUMAN (4-451): 0: 680: 68.15
+	Sc
		367127 HSP82_YEAST (1-705): 0: 968: 95.63		RUVB2_YEAST (1-471): 0: 707: 100.00
+	Ca
		804543 HSP90_CANAL (4-705): 0: 953: 82.36		RUVB2_CANAL (16-468): 0: 670: 81.80
+	Sc
		544350 HSC82_YEAST (1-705): 0: 977: 100.00		RUVB1_YEAST (8-448): 0: 624: 41.10
+	Sc
		366829 HSP82_YEAST (1-705): 0: 968: 95.63		RUVB1_YEAST (8-448): 0: 624: 41.10
+	Ca
		804508 HSP90_CANAL (4-705): 0: 953: 82.36		RUVB1_CANAL (14-445): 0: 620: 41.83