HitPredict

Interactor 1: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: CALR (P18418)
Calreticulin (CALBP) (CRP55) (Calcium-binding protein 3) (CABP3) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP)
Gene: CALR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008284 - positive regulation of cell population proliferation GO:0009897 - external side of plasma membrane GO:0016020 - membrane GO:0032355 - response to estradiol GO:0033574 - response to testosterone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1383 Rn			1 416
+	Hs
		411305 INSR_HUMAN (27-1383): 0: 1527: 95.43		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		160999 INSR_HUMAN (27-1383): 0: 1527: 95.43		CLGN_HUMAN (21-367): 2.18e-132: 395: 35.34
+	Hs
		435545 IGF1R_HUMAN (13-1381): 0: 1302: 55.77		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		161003 IGF1R_HUMAN (13-1381): 0: 1302: 55.77		CLGN_HUMAN (21-367): 2.18e-132: 395: 35.34
+	Hs
		654091 EPHA8_HUMAN (663-1323): 1.14e-174: 548: 22.59		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		654090 EPHA3_HUMAN (661-1320): 4.01e-172: 541: 24.15		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	At
		83441 Y1755_ARATH (517-1316): 0: 583: 15.01		CALX2_ARATH (25-363): 9.38e-118: 355: 31.90
+	Hs
		384313 NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95		CALR_HUMAN (18-416): 1.91e-180: 510: 89.25
+	Hs
		653574 MERTK_HUMAN (810-1302): 3.9e-61: 230: 31.54		CALR_HUMAN (18-416): 1.91e-180: 510: 89.25
+	Hs
		445825 ROS1_HUMAN (1020-1292): 1.06e-71: 267: 49.46		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		654899 ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		654092 LTK_HUMAN (1014-1292): 4.56e-70: 255: 43.82		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		384315 NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		654370 NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		337975 EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50		CALR_HUMAN (18-416): 1.91e-180: 510: 89.25
+	Hs
		160995 NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95		CLGN_HUMAN (21-367): 2.18e-132: 395: 35.34
+	Hs
		161071 NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80		CLGN_HUMAN (21-367): 2.18e-132: 395: 35.34
+	Hs
		601814 ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		337977 EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50		CALX_HUMAN (21-367): 4.2e-141: 416: 37.32
+	Hs
		161016 ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70		CLGN_HUMAN (21-367): 2.18e-132: 395: 35.34