HitPredict

Interactor 1: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: Q80ZA3 (Q80ZA3)
Serine (Or cysteine) peptidase inhibitor, clade F, member 1
Gene: Serpinf1

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010629 - negative regulation of gene expression GO:0030424 - axon GO:0043025 - neuronal cell body
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1383 Rn			1 418
+	Rn
		403561 INSR_RAT (1-1383): 0: 1575: 100.00		SPA3K_RAT (4-415): 2.31e-155: 446: 25.65
+	Hs
		411337 INSR_HUMAN (27-1383): 0: 1527: 95.43		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35
+	Hs
		435588 IGF1R_HUMAN (13-1381): 0: 1302: 55.77		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35
+	Hs
		384377 NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95		SPB6_HUMAN (51-415): 8.54e-144: 416: 24.27
+	Hs
		338114 EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50		SPB4_HUMAN (51-415): 9.78e-141: 408: 24.68
+	Hs
		338857 EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50		SPB12_HUMAN (51-415): 1.1e-130: 383: 22.41
+	Hs
		445832 ROS1_HUMAN (1020-1292): 1.06e-71: 267: 49.46		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35
+	Hs
		839705 ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35
+	Hs
		384501 NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35
+	Hs
		839579 MERTK_HUMAN (810-1302): 3.9e-61: 230: 31.54		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35
+	Hs
		839599 NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35
+	Hs
		609214 FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07		SERPH_HUMAN (54-415): 7.1e-31: 124: 27.35