HitPredict

Interactor 1: PVR (P15151)
Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
Gene: PVR

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30024968
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001618 - virus receptor activity GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016020 - membrane GO:0050862 - positive regulation of T cell receptor signaling pathway and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 417 Hs			1 236
+	Hs
		2727 A0A0C4DG49_HUMAN (1-417): 3.19e-84: 265: 99.76		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887951 CADM1_HUMAN (18-331): 2.1e-77: 248: 23.59		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887918 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887960 NECT3_HUMAN (26-389): 5.45e-69: 229: 24.20		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		602285 NECT3_HUMAN (26-389): 5.45e-69: 229: 24.20		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		887903 CADM4_HUMAN (1-395): 3.16e-61: 204: 20.50		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		888000 ROBO1_HUMAN (19-407): 1.02e-47: 177: 15.50		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		602297 ROBO1_HUMAN (19-407): 1.02e-47: 177: 15.50		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		1199563 TITIN_HUMAN (178-333): 3.86e-09: 61.2: 11.25		TSN33_HUMAN (9-233): 7.63e-51: 168: 22.78
+	Dm
		52381 A1Z7J1_DROME (28-344): 3.39e-14: 76.7: 16.18		Q7KJ73_DROME (3-234): 3.84e-44: 149: 21.37