HitPredict

Interactor 1: PVR (P15151)
Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
Gene: PVR

Interactor 2: TIGIT (Q495A1)
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
Gene: TIGIT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.865

Property	Details
Experiments	21982860, 27978489, 28515320
Identification Methods	pull down, surface plasmon resonance, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2-set_2~V-set, V-set~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 417 Hs			1 244
+	Hs
		1115376 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		TIGIT_HUMAN (1-244): 0: 527: 100.00
+	Hs
		1115382 NECT3_HUMAN (26-389): 5.45e-69: 229: 24.20		TIGIT_HUMAN (1-244): 0: 527: 100.00
+	Hs
		1115379 NECT4_HUMAN (1-334): 4.75e-64: 215: 26.47		TIGIT_HUMAN (1-244): 0: 527: 100.00