HitPredict

Interactor 1: PVR (P15151)
Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
Gene: PVR

Interactor 2: NT2NA (Q7Z3S9)
Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)
Gene: NOTCH2NLA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	25416956, 32296183, 31515488
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EGF~V-set
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 417 Hs			1 236
+	Hs
		1189382 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		NT2NA_HUMAN (1-236): 1e-44: 151: 100.00
+	Hs
		1189463 NECT3_HUMAN (26-389): 5.45e-69: 229: 24.20		NT2NA_HUMAN (1-236): 1e-44: 151: 100.00
+	Hs
		484560 PVR_HUMAN (1-417): 3.29e-84: 265: 100.00		NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95
+	Hs
		484677 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95
+	Hs
		484720 NECT3_HUMAN (26-389): 5.45e-69: 229: 24.20		NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95
+	Dm
		621592 Q9GPP7_DROME (28-372): 2.72e-38: 149: 15.04		SLIT_DROME (68-233): 1.89e-31: 123: 33.53
+	Dm
		621596 Q9VQ08_DROME (28-372): 2.1e-38: 149: 15.04		SLIT_DROME (68-233): 1.89e-31: 123: 33.53
+	Mm
		292557 ROBO1_MOUSE (19-395): 2.39e-47: 176: 14.95		SLIT3_MOUSE (71-188): 8.65e-12: 66.2: 27.05
+	Hs
		296682 ROBO1_HUMAN (19-407): 1.02e-47: 177: 15.50		SLIT2_HUMAN (68-185): 2.64e-10: 62: 32.52
+	Dm
		621597 Q9W213_DROME (241-415): 2.61e-25: 110: 12.77		SLIT_DROME (68-233): 1.89e-31: 123: 33.53
+	Dr
		1265014 Q90Z70_DANRE (19-332): 1.95e-44: 167: 15.29		Q9DE36_DANRE (26-204): 1.76e-09: 59.3: 22.46
+	Dm
		621595 Q9VPZ7_DROME (12-347): 6.5e-19: 91.6: 11.72		SLIT_DROME (68-233): 1.89e-31: 123: 33.53
+	Dm
		621591 Q9GPP6_DROME (12-347): 7.52e-19: 91.2: 11.72		SLIT_DROME (68-233): 1.89e-31: 123: 33.53
+	Dr
		65452 A8DZ85_DANRE (143-416): 1.07e-38: 150: 14.18		Q9DE36_DANRE (26-204): 1.76e-09: 59.3: 22.46
+	Dr
		65450 A8DZ85_DANRE (143-416): 1.07e-38: 150: 14.18		Q3Y6S4_DANRE (65-185): 6.13e-09: 57.7: 25.39
+	Hs
		804225 CNTN1_HUMAN (122-417): 5.21e-28: 118: 12.58		NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94
+	Hs
		980365 CNTN1_HUMAN (122-417): 5.21e-28: 118: 12.58		NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84
+	Hs
		980481 PXDN_HUMAN (19-241): 2.77e-26: 113: 16.00		NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84
+	Hs
		1055023 PSG8_HUMAN (16-247): 5.95e-11: 65.8: 13.92		FAT1_HUMAN (138-236): 1.66e-24: 103: 28.43
+	Dm
		422809 Q9BN17_DROME (28-338): 1.48e-12: 71.7: 15.27		NOTCH_DROME (10-236): 6.06e-15: 75.8: 21.99