HitPredict

Interactor 1: PVR (P15151)
Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
Gene: PVR

Interactor 2: NECT3 (Q9NQS3)
Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Gene: NECTIN3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	12759359, 22902367
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C2-set_2~C2-set_2, C2-set_2~V-set, V-set~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules GO:0007157 - heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0043296 - apical junction complex and 1 others more... GO:0050839 - cell adhesion molecule binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 417 Hs			1 549
+	Hs
		1269129 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		NECT3_HUMAN (49-549): 5.39e-105: 327: 100.00
+	Hs
		1343560 NECT3_HUMAN (26-389): 5.45e-69: 229: 24.20		NECT3_HUMAN (49-549): 5.39e-105: 327: 100.00
+	Mm
		1337519 NECT3_MOUSE (31-395): 2.25e-67: 225: 23.89		NECT3_MOUSE (18-549): 1.44e-105: 329: 93.23
+	Hs
		545146 PVR_HUMAN (1-417): 3.29e-84: 265: 100.00		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Mm
		692108 NECT2_MOUSE (25-334): 8.81e-72: 236: 54.75		NECT2_MOUSE (25-360): 3.76e-64: 220: 29.31
+	Hs
		1269111 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Mm
		1225063 Q8K094_MOUSE (1-400): 1.01e-66: 219: 38.88		Q8K094_MOUSE (35-360): 9.57e-69: 229: 29.64
+	Dm
		993926 ICCR_DROME (34-352): 1.05e-64: 222: 20.80		ICCR_DROME (39-409): 1.2e-63: 223: 19.53
+	Hs
		545112 PVR_HUMAN (1-417): 3.29e-84: 265: 100.00		CD226_HUMAN (37-208): 2.88e-42: 156: 27.01
+	Hs
		545122 PVR_HUMAN (1-417): 3.29e-84: 265: 100.00		SDK2_HUMAN (39-476): 2.32e-34: 140: 12.92
+	Hs
		1078223 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		CD226_HUMAN (37-208): 2.88e-42: 156: 27.01
+	Dr
		50501 B0CLW6_DANRE (11-330): 4.83e-68: 220: 33.44		A1L2D6_DANRE (44-193): 1.68e-37: 143: 26.97
+	Hs
		545110 PVR_HUMAN (1-417): 3.29e-84: 265: 100.00		NECT1_HUMAN (3-275): 1.18e-13: 75.5: 10.91
+	Hs
		1316126 CADM1_HUMAN (18-331): 2.1e-77: 248: 23.59		CADM1_HUMAN (4-255): 1.27e-18: 90.4: 14.90
+	Mm
		1246744 NECT4_MOUSE (1-352): 6.45e-73: 238: 25.91		NECT4_MOUSE (4-284): 5.23e-13: 73.4: 10.21
+	Hs
		1269115 NECT2_HUMAN (25-333): 4.43e-71: 234: 52.80		NECT4_HUMAN (4-263): 2.81e-12: 71.1: 11.03
+	Hs
		1069683 NECT3_HUMAN (26-389): 5.45e-69: 229: 24.20		NECT1_HUMAN (3-275): 1.18e-13: 75.5: 10.91
+	Hs
		1069681 NECT4_HUMAN (1-334): 4.75e-64: 215: 26.47		NECT1_HUMAN (3-275): 1.18e-13: 75.5: 10.91