HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	9490022, 11368848
Identification Methods	biochemical, two hybrid
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 204
+	Hs
		854769 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Mm
		925816 RAC1_MOUSE (1-192): 1.69e-84: 249: 92.19		GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06
+	Hs
		854759 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Mm
		892716 RAC3_MOUSE (1-191): 1.72e-78: 234: 89.01		GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06
+	Hs
		854771 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		854760 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Rn
		901290 RHOA_RAT (5-192): 4.13e-76: 228: 54.26		GDIR1_RAT (1-204): 6.26e-117: 332: 97.06
+	Hs
		854851 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		925561 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	Hs
		545279 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Dm
		816393 RHO1_DROME (5-192): 3.82e-94: 273: 55.85		Q9VW59_DROME (16-202): 2.38e-83: 247: 50.53
+	Mm
		892713 RAC3_MOUSE (1-191): 1.72e-78: 234: 89.01		GDIR2_MOUSE (13-204): 1.25e-98: 285: 68.75
+	Hs
		854847 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		854852 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		951270 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	Hs
		894357 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	At
		1105170 RAC5_ARATH (4-177): 3.51e-79: 236: 65.52		GDIR_ARATH (2-202): 4.35e-89: 263: 37.86
+	Cl
		47354 RAC1_CANLF (1-192): 1.69e-84: 249: 92.19		A0A8I3N6C6_CANLF (1-204): 3.52e-81: 240: 76.47
+	Ce
		975573 RAC1_CAEEL (1-192): 6e-83: 245: 79.69		GDIR_CAEEL (20-201): 2.64e-75: 226: 38.80
+	Sc
		580337 CDC42_YEAST (1-192): 5.43e-76: 227: 67.19		GDIR_YEAST (19-200): 5.15e-69: 211: 37.90