HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: ITPR3 (Q14573)
Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Gene: ITPR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 2671
+	Hs
		950998 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		894011 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		900471 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		545379 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		892374 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		950999 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		894014 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		894010 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		ITPR2_HUMAN (3-2663): 0: 3897: 64.52
+	Hs
		900474 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		900470 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		ITPR2_HUMAN (3-2663): 0: 3897: 64.52
+	Hs
		436303 RHOC_HUMAN (5-192): 1.83e-73: 221: 54.79		ITPR1_HUMAN (2-2663): 0: 3900: 60.67