HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: CYFP1 (Q7L576)
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)
Gene: CYFIP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0008360 - regulation of cell shape GO:0010592 - positive regulation of lamellipodium assembly GO:0030027 - lamellipodium and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 1253
+	Hs
		925386 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Mm
		925800 RAC1_MOUSE (1-192): 1.69e-84: 249: 92.19		CYFP1_MOUSE (1-1253): 0: 2079: 99.04
+	Hs
		892449 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		925513 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		951104 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		894162 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		545555 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		900624 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		892535 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		951231 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Mm
		1143609 RHOC_MOUSE (5-192): 1.83e-73: 221: 54.79		CYFP1_MOUSE (1-1253): 0: 2079: 99.04
+	Hs
		900789 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Dm
		776913 RAC1_DROME (1-192): 7.95e-82: 242: 89.06		CYFIP_DROME (1-1253): 0: 1903: 65.73
+	At
		1105134 RAC4_ARATH (4-177): 8.27e-80: 237: 64.94		PIR_ARATH (5-1240): 0: 1535: 28.88
+	At
		1105163 RAC5_ARATH (4-177): 3.51e-79: 236: 65.52		PIR_ARATH (5-1240): 0: 1535: 28.88
+	At
		1105104 RAC1_ARATH (4-177): 4.54e-78: 233: 64.37		PIR_ARATH (5-1240): 0: 1535: 28.88
+	At
		1105123 RAC3_ARATH (2-192): 1.67e-71: 216: 61.22		PIR_ARATH (5-1240): 0: 1535: 28.88