HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: DOCK2 (Q92608)
Dedicator of cytokinesis protein 2
Gene: DOCK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.777

Property	Details
Experiments	10559471, 14737186
Identification Methods	pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0006935 - chemotaxis GO:0007264 - small GTPase-mediated signal transduction and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1830
+	Hs
		925486 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK2_HUMAN (1-1830): 0: 2494: 100.00
+	Hs
		925276 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK1_HUMAN (1-1783): 0: 2214: 59.96
+	Hs
		545372 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK1_HUMAN (1-1783): 0: 2214: 59.96
+	Mm
		925807 RAC1_MOUSE (1-192): 1.69e-84: 249: 92.19		DOCK1_MOUSE (1-1783): 0: 2199: 59.82
+	Hs
		925620 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK5_HUMAN (1-1750): 0: 2121: 55.64
+	Hs
		545622 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK5_HUMAN (1-1750): 0: 2121: 55.64
+	Hs
		925425 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK3_HUMAN (4-1657): 0: 1911: 37.48
+	Hs
		925429 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK4_HUMAN (4-1613): 0: 1841: 38.62
+	Dm
		776892 RAC1_DROME (1-192): 7.95e-82: 242: 89.06		Q8MQW7_DROME (663-1762): 0: 1240: 38.62
+	Hs
		925588 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK9_HUMAN (301-930): 4.1e-126: 442: 15.73
+	Hs
		564671 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DOCK9_HUMAN (301-930): 4.1e-126: 442: 15.73
+	Hs
		545596 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK9_HUMAN (301-930): 4.1e-126: 442: 15.73
+	Hs
		925332 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOC11_HUMAN (318-944): 3.78e-123: 433: 17.01
+	Hs
		564557 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DOC11_HUMAN (318-944): 3.78e-123: 433: 17.01
+	Hs
		545421 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOC11_HUMAN (318-944): 3.78e-123: 433: 17.01
+	Hs
		925448 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK8_HUMAN (307-716): 1.43e-101: 365: 17.63
+	Hs
		925518 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK6_HUMAN (301-860): 1.39e-63: 243: 16.24
+	Hs
		925526 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK7_HUMAN (302-1131): 2.97e-58: 225: 14.89
+	At
		1105136 RAC4_ARATH (4-177): 8.27e-80: 237: 64.94		SPK1_ARATH (426-977): 1.23e-27: 124: 14.38
+	At
		1105166 RAC5_ARATH (4-177): 3.51e-79: 236: 65.52		SPK1_ARATH (426-977): 1.23e-27: 124: 14.38