HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 889
+	Hs
		925589 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		564672 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		892574 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		951303 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		894394 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		564655 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		545575 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		925615 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		545617 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		925582 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		892595 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		951338 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		545593 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		951289 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		894383 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		925581 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		564667 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		545592 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		951288 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Sc
		580309 CDC42_YEAST (1-192): 5.43e-76: 227: 67.19		KES1_YEAST (399-733): 5.95e-92: 299: 26.83