HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: DIAP3 (Q9NSV4)
Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2)
Gene: DIAPH3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0043131 - erythrocyte enucleation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1193
+	Hs
		925658 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DIAP3_HUMAN (1-1193): 0: 1085: 100.00
+	Hs
		564704 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DIAP3_HUMAN (1-1193): 0: 1085: 100.00
+	Hs
		925759 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		564754 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		545717 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		545484 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		FMNL3_HUMAN (92-1091): 0: 665: 20.44
+	Hs
		925531 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		FMNL2_HUMAN (112-1089): 0: 653: 21.45
+	Hs
		237586 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DIAP1_HUMAN (20-635): 3.9e-134: 442: 37.97
+	Hs
		243100 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		243091 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		243089 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		925315 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		INF2_HUMAN (612-1179): 3.52e-123: 412: 22.30
+	Hs
		545409 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		INF2_HUMAN (612-1179): 3.52e-123: 412: 22.30
+	Dm
		112307 RHO1_DROME (5-192): 3.82e-94: 273: 55.85		M9MRS9_DROME (444-1128): 9.25e-111: 379: 17.80
+	Hs
		925768 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		FHOD1_HUMAN (130-1175): 1.1e-113: 384: 15.79
+	Dm
		112306 RAC1_DROME (1-192): 7.95e-82: 242: 89.06		M9MRS9_DROME (444-1128): 9.25e-111: 379: 17.80
+	Hs
		925673 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		FMN2_HUMAN (595-1059): 8.72e-101: 354: 24.08
+	Hs
		314858 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		FMNL1_HUMAN (116-548): 1.04e-80: 289: 17.78
+	Hs
		314838 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		FMNL1_HUMAN (116-548): 1.04e-80: 289: 17.78
+	Dm
		816376 RHO1_DROME (5-192): 3.82e-94: 273: 55.85		CAPU_DROME (665-1055): 2.16e-24: 112: 24.82