HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: PLXA1 (Q9UIW2)
Plexin-A1 (Semaphorin receptor NOV)
Gene: PLXNA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape GO:0030334 - regulation of cell migration GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1896
+	Hs
		925714 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		892670 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		951446 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		894567 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		901031 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		165187 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165157 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165155 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165179 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165189 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165180 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165182 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Dm
		816387 RHO1_DROME (5-192): 3.82e-94: 273: 55.85		PLXB_DROME (45-1109): 0: 848: 27.10
+	Dm
		776907 RAC1_DROME (1-192): 7.95e-82: 242: 89.06		PLXB_DROME (45-1109): 0: 848: 27.10
+	Dm
		819748 RAC2_DROME (1-192): 2.88e-80: 238: 88.02		PLXB_DROME (45-1109): 0: 848: 27.10
+	Hs
		925450 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		564678 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		SEM6A_HUMAN (6-549): 2.71e-119: 406: 16.36
+	Hs
		900707 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		441478 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		MET_HUMAN (814-1212): 1.56e-103: 367: 25.80
+	Hs
		195972 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		PLXB1_HUMAN (558-875): 1.91e-12: 75.2: 18.58